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วันศุกร์ที่ 8 มิถุนายน พ.ศ. 2555

Visible Signs Of Aging Improved By Pycnogenol (French Maritime Pine Bark Extract) In New Study

Main Category: Cosmetic Medicine / Plastic Surgery
Also Included In: Seniors / Aging;  Dermatology;  Women's Health / Gynecology
Article Date: 26 Jan 2012 - 1:00 PST Current ratings for:
'Visible Signs Of Aging Improved By Pycnogenol (French Maritime Pine Bark Extract) In New Study'
3 and a half stars4 stars
Human skin is the body's first line of defense and often mirrors the health, nutritional status and age of a person. Over time, skin shows signs of aging due to the gradual breakdown of collagen and elastin. However, skin can be rebuilt and made healthier no matter one's age. Natural supplement Pycnogenol? (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, was found to improve skin hydration and elasticity in women in a clinical trial published this month in Skin Pharmacology and Physiology.

The study was conducted at the Leibniz Research Institute for Environmental Medicine (IUF) in Dusseldorf, Germany and examined 20 healthy women, aged 55 - 68 years. Participants were given 75 mg of Pycnogenol? per day, over a period of 12 weeks. Skin hydration, skin elasticity and skin fatigue were assessed by non-invasive biophysical methods at trial start and after six and 12 weeks. In addition, at the beginning and again after 12 weeks of Pycnogenol? supplementation, each time, a biopsy was obtained to assess gene expression of HAS-1 and COL1A1 and COL1A2. The study found that: Pycnogenol? elevated COL1A1 by 29 percent and COL1A2 by 41 percent and increased hyaluronic acid production in skin by 44 percent Pycnogenol? enhanced skin elasticity by 25 percent, in addition to skin hydration by eight percent, and was especially noticeable in women who had dry skin from the start, with an increase of 21 percent Pycnogenol? decreased skin fatigue considerably Pycnogenol? reduced skin wrinkles by three percent and increased skin smoothness by six percent "To date, Pycnogenol? is the only natural supplement that stimulates hyaluronic acid production in human skin. And, we are encouraged by the molecular evidence confirmed in this study that shows nutritional supplementation with Pycnogenol? benefits human skin," explains Dr. Jean Krutmann, the lead researcher from the Leibniz Research Institute in Dusseldorf, Germany.

Study results confirmed Pycnogenol? improved skin at a physiological and molecular level. Pycnogenol? increased hyaluronic acid in women by 44 percent after 12 weeks of supplementation. Hyaluronic acid binds large quantities of water in the skin and in other tissues, such as cartilage. An increased amount of hyaluronic acid explains the increased skin hydration, higher elasticity and overall smoother skin appearance found in women taking Pycnogenol?.

"This exciting and technically advanced investigation with women representing actual consumer profiles greatly supports our efforts for targeting the skin beauty category for both dietary supplements and functional foods," says Victor Ferrari, CEO of Horphag Research, exclusive worldwide suppliers of Pycnogenol?, who welcomes the publication.

According to Ferrari, beauty from within has been a driver in Horphag's business for the last several years, with Asian markets providing numerous Pycnogenol? products in the skincare field. This study joins a sizable and largely expanding portfolio of already established skin research on Pycnogenol?. It confirms previous indications that Pycnogenol? improves human skin conditions, including promoting glowing skin and reducing the appearance of over-pigmentation and skin inflammation, resulting in a more even complexion.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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'Visible Signs Of Aging Improved By Pycnogenol (French Maritime Pine Bark Extract) In New Study'

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Physicists Devise Method For Building Artificial Tissue

Main Category: Pharma Industry / Biotech Industry
Also Included In: Cosmetic Medicine / Plastic Surgery
Article Date: 30 May 2012 - 0:00 PDT Current ratings for:
'Physicists Devise Method For Building Artificial Tissue'
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New York University physicists have developed a method that models biological cell-to-cell adhesion that could also have industrial applications.

This system, created in the laboratory of Jasna Brujic, an assistant professor in NYU's Department of Physics and part of its Center for Soft Matter Research, is an oil-in-water solution whose surface properties reproduce those found on biological cells. Specifically, adhesion between compressed oil droplets mimics the mechanical properties of tissues and opens the path to numerous practical applications, ranging from biocompatible cosmetics to artificial tissue engineering.

Their method is described in the journal the Proceedings of the National Academy of Sciences.

Previously, Bruji?'s laboratory has determined how spheres pack and devised methods for manipulating the packing process. In this PNAS study, Bruji? and her research team sought to create a method that would address the role of packing in tissues from the point of view of how mechanical forces affect protein-protein adhesion between cells.

In biology, cell-to-cell adhesion is crucial to the integrity of tissue structure - cells must come together and stick in order to ensure tissue cohesion. However, the daunting complexity of biological systems has long prevented their description using general theoretical concepts taken from the physical sciences. For this reason, the research team designed an original biomimetic solution, or emulsion, that reproduces the main features of cell-to-cell adhesion in tissues.

Emulsions form the basis for a range of consumer products, including butter, ice cream, and milk. In addition, the emulsion in the PNAS study is tuned to match the attractive and repulsive interactions that govern adhesion between cells. The experimental conditions reveal the circumstances under which pushing forces are necessary to create adhesion.

By varying the amount of force by which the droplets of oil were compressed by centrifugation and the amount of salt added to this solution, the NYU team was able to isolate the optimal conditions for cell-to-cell adhesion. Screening electrostatic charges by the addition of salt and compressing the droplets by force enhances protein-protein interactions on the droplet surfaces. This leads to adhesion between contacting droplets covering all the interfaces, just as in the case of biological tissues.

Their results, which matched the researchers' theoretical modeling of the process, offer a method for manipulating force and pressure in order to bind emulsions. This serves as a starting point for enriching a range of consumer products, by reconfiguring their molecular make-up to enhance consistency and function, and for improving pharmaceuticals, by bolstering the delivery of therapeutic molecules to the blood stream.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our pharma industry / biotech industry section for the latest news on this subject. The study's other authors were Lea-Laetitia Pontani, a postdoctoral research scientist, and Ivane Jorjadze, a graduate student, both from NYU's Department of Physics and the Center for Soft Matter Research, as well as Virgile Viasnoff, an Associate Professor at the National University of Singapore and the French research institute, CNRS/ESPCI.
The research was performed in the NYU Materials Research Science and Engineering Center (MRSEC), which is supported by the National Science Foundation.
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8 Jun. 2012. APA

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Tips For African-American Patients To Reduce Their Risk Of Developing A Hair Or Scalp Disease

Main Category: Dermatology
Also Included In: Cosmetic Medicine / Plastic Surgery;  Epilepsy
Article Date: 21 Mar 2012 - 0:00 PDT Current ratings for:
'Tips For African-American Patients To Reduce Their Risk Of Developing A Hair Or Scalp Disease'
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Styling practices can lead to serious hair and scalp diseases for some African Americans, says Henry Ford Hospital dermatologist Diane Jackson-Richards, M.D.

"Hair is an extremely important aspect of an African-American woman's appearance," says Dr. Jackson-Richards, director of Henry Ford's Multicultural Dermatology Clinic. "Yet, many women who have a hair or scalp disease do not feel their physician takes them seriously. Physicians should become more familiar with the culturally accepted treatments for these diseases."

Dr. Jackson-Richards says proper hair care can help prevent the onset of such diseases like seborrheic dermatitis and alopecia, and that dermatologists need to become more sensitive to the hair and scalp plights of African Americans.

Dr. Jackson-Richards will discuss these issues Monday during a presentation of "Hair Disease and the African-American Patient" at the annual American Academy of Dermatology conference in San Diego.

Little research has been done about the prevalence and causes of hair and scalp diseases in African Americans. Dr. Jackson-Richards says understanding the unique physiologic characteristics of African textured hair - for example, it grows slower and has a lower hair density than other ethnic groups - will assist dermatologists in prescribing treatment options.

African-American women are known to shampoo their hair less frequently than other ethnic groups, and an estimated 80 percent of them use chemical relaxers. Frequent use of blow dryers and hot combs, combined with popular hair styles like hair weaves, braids and dreadlocks, add physical stress to the hair and contribute to scalp diseases like alopecia, or hair loss.

"Hair loss is the fifth most common condition cited by patients when they visit their dermatologist," Dr. Jackson-Richards says.

Dr. Jackson-Richards suggests these grooming tips for patients to reduce their risk of developing a hair or scalp disease: Wash hair weekly with a moisturizing shampoo and conditioner. Allow two weeks between relaxing and coloring. Limit use of blow dryers and hot combs and other heated hair styling products to once a week. Wash braids or dreadlocks every two weeks. Avoid wearing braids too tightly; don't wear longer than three months. To detangle hair, use a wide tooth comb while conditioner is still in the hair. Use natural hair oils with jojoba, olive, shea or coconut oils.Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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Plastic Surgeries Continue To Grow, Despite Sluggish Economy, USA

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Main Category: Cosmetic Medicine / Plastic Surgery
Article Date: 11 Feb 2012 - 10:00 PST Current ratings for:
'Plastic Surgeries Continue To Grow, Despite Sluggish Economy, USA'
1 and a half stars4 stars
13.8 million plastic surgery procedures were performed in 2011, a 5% increase on the year before, according to a new report issued by the American Society of Plastic Surgeons (ASPS). The authors added that by the end of 2011, the number of total plastic surgeries had grown for 24 consecutive months. These figures include both minimally-invasive and surgical procedures.

The ASPS informs that 5.5 additional reconstructive procedures were carried out in 2011, also a 5% increase on the previous year.

ASPS President Malcolm Z. Roth, MD., said:

"While the rate of economic recovery in the U.S. is still uncertain, 2011 proved to be a good year for plastic surgery. Consumer confidence was up, auto sales rose 10 percent, so it is not surprising that we would also see increased demand for plastic surgery procedures."
1.6 cosmetic procedures were performed in 2011, a 2% increase over the previous year. Below are some details on the top five in 2011 compared to 2010: Breast implant - 307,000. A rise of 4%Rhinoplasty (nose job) - 244,000. A reduction of 3%Liposuction - 205,000. A rise of 1%Blepharoplasty (eyelid surgery) - 196,000. A drop of 6%Rhytidectomy (facelift) - 119,00. A rise of 5%Facelifts replaced tummy tucks for fifth place last year; the first time that procedure was among the top five since 2004.

Chin augmentations, also known as "chin implants", rose 71% to 21,000 procedures in 2011.

Lip enhancement, also known as "lip augmentation" increased by 49% to 25,000 procedures carried out last year.

Dr. Roth said:

"We are seeing notable increases in surgical procedures, such as facelifts, that reflect the demands of an aging boomer population. However, the overall growth in cosmetic procedures is being primarily driven by a substantial rise in minimally-invasive procedures."
There were 12.2 million minimally-invasive procedures last year, a rise of 6%. Below are some details of the top five most popular in 2011: Botulinum toxin type A - 5.7 million. A rise of 5%Soft tissue filler - 1.9 million. A rise of 7%Chemical peel - 1.1 million. A fall of 3%Laser hair removal - 1.1 million. A rise of 15%Microdermabrasion - 900,000. A rise of 9%Among the increases that stood out in 2011 for minimally-invasive procedures were soft tissue fillers, such as calcium hydroxylapatite (Radiesse?), fat injections, and hyaluronic acid (Restylane?, Juvederm Ultra?). Below are some details on totals for 2011, and how they compared to the previous year: Hylauronic acid procedures - over 1.3 million. A rise of 9%Calcium hydroxylapatite procedures - 286,000. A rise of 36%Fat injections - 68,000. A rise of 19%This type of surgery, which aims to improve the appearance of abnormal structures, as well as function, increased by 5% in 2011 compared to the previous year. Below are details on the top five reconstructive plastic surgery procedures: Removing a tumor - 4.2 million. A rise of 3%Laceration repair - 303,000. A drop of 15%Maxillofacial surgery - 195,000. A rise of 125%Scar revision - 175,000. A rise of 9%Hand surgery - 120,000. A rise of 13%There were 96,000 breast reconstruction procedures in 2011, a rise of 3% compared to the previous year.

Dr. Roth said:

"While insurance coverage for breast reconstruction is mandated by law, continued strides to provide coverage for other reconstructive procedures has contributed, in part, to the sizable gain that we are seeing with these procedures. Reconstructive surgery is a critical pillar of the specialty, and it is encouraging to see that increasing numbers of patients entrust board-certified plastic surgeons to reconstruct their bodies after disease or trauma."

Written by Christian Nordqvist
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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Christian Nordqvist. "Plastic Surgeries Continue To Grow, Despite Sluggish Economy, USA." Medical News Today. MediLexicon, Intl., 11 Feb. 2012. Web.
8 Jun. 2012. APA

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Head And Facial Abnormal Features Repair Themselves

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Main Category: Dermatology
Also Included In: Cosmetic Medicine / Plastic Surgery
Article Date: 02 May 2012 - 9:00 PDT Current ratings for:
'Head And Facial Abnormal Features Repair Themselves'
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A report in the May issue of the journal Developmental Dynamics reveals that biologists from the Tufts University have, for the first time, discovered a "self-correcting" mechanism by which developing organisms recognize and repair head and facial abnormalities.

This is the first time that this kind of flexible, corrective process has been rigorously analyzed through mathematical modeling.

The study demonstrates that developing organisms are not genetically "hard-wired", but that the process is, instead, more flexible and robust. By using a tadpole model with a set of pre-determined cell movements that result in normal facial features, they demonstrated that cell groups can measure their shape and position in relationship to other organs, as well as performing the required movements and remodeling functions in order to compensate for important abnormalities in patterns.

Senior researcher, Michael Levin, Ph.D., director of the Center for Regenerative and Developmental Biology in Tufts University's School of Arts and Sciences explained:

"A big question has always been, how do complex shapes like the face or the whole embryo put themselves together? We have found that when we created defects in the face experimentally, facial structures move around in various ways and mostly end up in their correct positions. This suggests that what the genome encodes ultimately is a set of dynamic, flexible behaviors by which the cells are able to make adjustments to build specific complex structures. If we could learn how to bioengineer systems that reliably self-assembled and repaired deviations from the desired target shape, regenerative medicine, robotics, and even space exploration would be transformed."

Earlier research had discovered self-correcting mechanisms in other embryonic processes, yet never in the face. These mechanisms had not been analyzed mathematically to shed a light onto the corrective process' precise dynamics.

Leading researcher, Laura Vandenberg, Ph.D., a post-doctoral associate at the Center for Regenerative and Developmental Biology said:

"What was missing from previous studies - and to our knowledge had never been done in an animal model - was to precisely track those changes over time and quantitatively compare them."

An analysis like this is vital for gaining insight into what information is being generated and manipulated so that a complex structure can rearrange and repair itself.

The team of biologists made one side of the embryos abnormal by injecting specific mRNA into one cell at the two-cell stage of development, which induced craniofacial defects in Xenopus frog embryos.

They then characterized changes of the craniofacial structures in terms of their shape and position, including jaws, eyes, branchial arches, otic capsules and olfactory pits by performing a 'geometric morphometric analysis' that measures the position of 32 landmarks on tadpoles' top and bottom sides.

By taking images of tadpoles at precise intervals, the researchers observed that the craniofacial abnormalities (perturbations), in particular, in the jaws and branchial arches became less apparent as the tadpoles aged. They also noted that the tadpoles' eye and nose tissue became more normal over time, although they did note various differences in achieving a completely expected shape and position.

In any baby animal it is a normal part of development that facial features change in terms of their shape and position. As the animal gets older, their faces elongate and their eyes, nose and jaws grow in relation to each other, even though the movement is generally fairly marginal.

The team observed, however, that in tadpoles with severe malformation, a major dramatic shift occurred in the facial structures in order to repair those malformations. They stated that it appeared as if the system was able to detect deviations from the normal state and perform corrective actions that would not typically take place.

"We were quite astounded to see that, long before they underwent metamorphosis and became frogs, these tadpoles had normal looking faces. Imagine the implications of an animal with a severe 'birth defect' that, with time alone, can correct that defect."

The biologists state that the findings were consistent with an information exchange process in which a structure triangulates its distance and angle from a stable reference point. They say that although further studies are required, they suggest exchanging 'pings', i.e. signals that contain information between an 'organizing center' like the brain and neural network and individual craniofacial structures.

The researchers highlight the fact that birth defects, such as cleft lips, cleft palate and microphthalmia affect over 1 in 600 births. New approaches of correcting these birth defects that belong to the category of congenital malformations of craniofacial structures could potentially be corrected in humans by conducting further studies at the molecular level, which would shed more light on the "face-fixing" dynamics.

Levin concluded:

"Such understanding would have huge implications not only for repairing birth defects, but also for other areas of systems biology and complexity science. It could help us build hybrid bioengineered systems, for synthetic or regenerative biology, or entirely artificial robotic systems that can repair themselves after damage or reconfigure their own structure to match changing needs in a complex environment."

Written By Petra Rattue
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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8 Jun. 2012. APA

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PIP Breast Implants - UK Dept Of Health Response To Expert Report

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Main Category: Cosmetic Medicine / Plastic Surgery
Article Date: 13 Jan 2012 - 9:00 PST Current ratings for:
'PIP Breast Implants - UK Dept Of Health Response To Expert Report'
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According to the Department of Health, their main concern is the wellbeing of women who have had PiP breast implants. For this reason, an expert group led by Professor Sir Bruce Keogh, NHS Medical Director, has been asked to examine all available data and evidence on PiP breast implants.

The experts concluded that: There is no association with PiP breast implants and cancer Advice given by the MHRA still stands That there is insufficient evidence to recommend routine extraction of PiP breast implants. However, the group explains that these implants should have never been implanted in women in the first place, as they are made up of non-medical grade silicone. The Department of Health knows that this data will be a worrying for women who have PiP implants. Those who performed the implantations should properly support these women.

Patients with concerns regarding this issue should talk to their GP (general practitioner, primary care physician), or surgeon.

If the woman still has concerns after consulting with her doctor and decides to remove the implants, the NHS will support the removal and replace the implants if the original breast implants was done by the NHS.

The Department of Health expects that those in the private sector do the same for their patients, as private providers have a responsibility to provide appropriate after-care to individuals they have treated as they have legal obligations to their patients.

The NHS will offer a package of care for its patients, and The Department of Health expects the private sector to do the same.

The NHS offer is: The NHS will contact all individuals who have received breast implants from the NHS in order to inform them that they have a PIP implant and provide relevant information and advice. The NHS will provide information free of charge should patients seek information about the make of their implant. Consultations with their GP, or with the surgical team who conducted the original implant, should the women seek clinical advice on the best way forward. Consultations may include imaging scans to determine whether there is any evidence the implant has ruptured. The NHS will remove PIP implants if a woman (with her doctor) decides that it is the right thing to do, and and there is an assessed clinical need. If the original procedure was conducted by the NHS, the NHS will replace the implants. The Department of Health is collaborating with the private sector to make sure an equivalent model of care is provided, as it's unfair for the taxpayer for the NHS to pay the bill.

The NHS will support removal of PiP implants, in line with the guidance above, should the clinic that carried out the operation refuses to care for their patient - where the patient is entitled to NHS services, or no longer exists. The replacement of private cosmetic implants would not be included by any NHS service in that respect. In order to avoid the taxpayer footing the bill, the Government will pursue private clinics with all means at its disposal.

However, the experts are unsure whether the rapture rate is higher for PiP implants than other breast implants.

Studies reveal that if a PiP implant did rupture, there is no risk of dangerous toxins leaking into the body, although the experts are not confident that the manufacturer did not alter the silicone in the implants and therefore cannot rule out that some implants may be toxic.

According to the Department of Health:

"We need to do everything we can to ensure the safety of people having cosmetic surgery.

It's clear from the information we have received from the industry that the safety information it has provided to the regulator is patchy. Without good data, we have no way of knowing when problems arise."

The expert group will analyze the broader issues surrounding the quality of surveillance, data, and enforcement of the sector and sector regulation more generally.

Evidence of providers' compliance with registration requirements are being reviewed by The Care Quality Commission as well as considering a fuller program of inspections.

In addition, the UK and France will continue to collaborate in sharing data and information. Both nations are determined to prevent this situation from happening again. The UK would like to collaborate with countries across the EU in order to fully understand where the failures of this incident fall.

Health Secretary Andrew Lansley explained:

"Throughout the past few weeks, my main concern has been for the safety of and compassion for women who have PIP implants. It has been a worrying time for these women. We have at every stage sought to offer them as much advice and evidence as is available to us.

Our advice remains the same that there is not sufficient evidence to recommend routine removal. We have always recommended that women who are concerned should speak to their surgeon or GP. The NHS will support removal of PIP implants if, after this consultation, the patient still has concerns and with her doctor she decides that it is right to do so.

We believe that private healthcare providers have a moral duty to offer the same service to their patients that we will offer to NHS patients - free information, consultations, scans, and removal if necessary.

Throughout this process we have followed expert advice. The data available to the experts has not been good enough to enable them to give a clear recommendation of the risk posed by PIP implants. We will therefore support women, including removal of the implant, if needed."

Professor Sir Bruce Keogh said:

"The overriding consideration of the group is the safety and compassionate treatment of women with PiP implants.

On the basis of the information we have, we do not think it is necessary to recommend the routine removal of these implants. But we understand that some women will be very concerned so we support the Government's position that the NHS will support removal of PIP implants if the patient has concerns and with her doctor she decides that it is right to do so."

Written by Grace Rattue
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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Grace Rattue. "PIP Breast Implants - UK Dept Of Health Response To Expert Report." Medical News Today. MediLexicon, Intl., 13 Jan. 2012. Web.
8 Jun. 2012. APA

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posted by julie on 14 Jan 2012 at 1:24 pm

Every thing on/in my body is original. I thank God every day for what he gave me even if I never win any beauty contests.

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posted by Georgina on 14 Jan 2012 at 8:11 am

ive been to see my doctor and was told they ae not willing to send me for a breast scan or examine me untill they have writen conformation from the private clinic where i had my surgery confirming that i have had surgery on my breasts , Im sure if the doctor had bothered to examine my breast she would have felt the implants and seen the small scares that i have. im really upset with the way the doctor spoke to me has she told me because i had them done private she doesnt see why she should treat me now . I told her that i thought it was her place to treat me has im not asking her to take the implants out but just check that they are ok , I also told her that i had symptoms of the implants leeking and she never asked me what my symptoms are. Ive now made an appointment to see one of the partners at my doctors surgery and see if i get the same answers.

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'PIP Breast Implants - UK Dept Of Health Response To Expert Report'

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Inhibitor Causing Male Pattern Baldness Discovered

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Academic Journal
Main Category: Cosmetic Medicine / Plastic Surgery
Also Included In: Dermatology
Article Date: 23 Mar 2012 - 1:00 PDT Current ratings for:
'Inhibitor Causing Male Pattern Baldness Discovered'
4 and a half stars4 stars
A study published in Science Translational Medicine, from the University of Pennsylvania, explains that scientists looking for the holy grail in beauty treatment have discovered an abnormal quantity of a protein, called Prostaglandin D2, present in the scalp of bald men, that they think may be responsible for their hair loss.

Their work should lead directly to the creation of new treatments for the most common cause of hair loss in men, known as male pattern baldness. The problem of male pattern baldness is seen to varying degrees in 8 of 10 men under 70 years old. It causes hair follicles to shrink and produce microscopic hairs. These grow for a shorter duration than normal follicles, meaning that follicles just don't replace at the fast enough rate for the loss of normal ones.

The prostaglandin, known as PGD2 and its derivative, 15-dPGJ2, have been shown to inhibit hair growth in both human and animal models. The PGD2-related inhibition is associated with a receptor: GPR44, which is now looking as though it will be a promising therapeutic target for androgenetic alopecia (AGA) in both men and women with hair loss and thinning.

George Cotsarelis, MD, chair and professor of Dermatology, and senior author on the studies, explains how his work is building on a previous study from Penn. University published in the Journal of Clinical Investigation last year :

"Although a different prostaglandin was known to increase hair growth, our findings were unexpected, as prostaglandins haven't been thought about in relation to hair loss, yet it made sense that there was an inhibitor of hair growth, based on our earlier work looking at hair follicle stem cells."

More importantly, and giving hope to millions of bald people everywhere, it appears that the underlying hair follicle stem cells are intact. This seems to suggest that the scalp is either lacking an activator or has been inhibited from creating new follicle growth. In the past, general thinking was that the follicles had died permanently, hence leading baldness treatments have involved using new follicles taken from elsewhere on the scalp.

Researchers write that they took an unbiased approach when searching for possible biological causes of baldness. They looked in scalp tissue from balding and non-bald spots from men with male pattern baldness. They then cross-checked their findings in mouse models, where levels of PGD2 were elevated in bald scalp tissue at levels 3 times greater than what was found in comparative haired scalp of men with androgenetic alopecia.

When PGD2 was added to cultured hair follicles, PGD2-treated hair was significantly shortened, while PGD2's derivative, 15-dPGJ2, completely inhibited hair growth.

Prostaglandins are well understood in their role in many bodily functions. They control cell growth, constrict and dilate smooth muscle tissue, and a different prostaglandin (F2alpha) has been seen to increase hair growth. PGD2 on the other hand, inhibits hair growth.

The researchers also make note that prostaglandins may represent a common pathway shared by both men and women with AGA, although so far, they have only looked at male test results. A topical treatment to target GPR44, will determine whether focusing on prostaglandins will benefit women with AGA as well.

Written by Rupert Shepherd
Copyright: Medical News Today
Not to be reproduced without permission of Medical News Today

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posted by Dr Rafiq Tareen Pathan on 4 Apr 2012 at 8:25 am

After reading this article , it confirms to someextend that the UVB PHtotherapy used in AGA shows the results as it suppresses the activity of Prostaglandins inhibiting the Hair growth. I do see good results of using the UVB PHOTOTHERAPY withy Minoxidil etc.

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posted by Kaku Kyiamah on 29 Mar 2012 at 2:52 pm

Prostaglandins are produced by polyunsaturated fatty acids, which enter the body when we eat polyunsaturated vegetable oils and unfermented grains. Polyunsaturated fatty acids do no useful work in the body. Prostaglandins have been identified as being involved in many diseases, including the formation of atherosclerotic plaque in heart attacks, cancers, asthma, erectile dysfunction in men, dysmenorrhea (menstrual pains)and inelastic vagina in women. Why eat polyunsaturated vegetable oils (thanks to FDA and AHA) and then get ailments and diseases which are difficult to cure.

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posted by micah on 28 Mar 2012 at 8:13 am

alright, now they need to pump out some medicine to fix it!

I neeeed hair!

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posted by Pete Watkins on 22 Mar 2012 at 3:16 pm

THANK GOD! It is about time we solve this issue. I have been fighting male pattern baldness for several years now (topical and propecia) I hope they fast track this medicine as it would greatly improve my quality of living. I have also written my senator to sponsor legislation that this be "medically necessary" and require insurance companies to provide for free Propecia and Minoxidil!!

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posted by Steve Wood on 22 Mar 2012 at 1:32 pm

You can use Polysorbite 80 on your folicles and reduce the DHT in yout scalp and regrow hair. The FDA dis alowed it years ago, It's safe on inexpensive.Wh oare they protecting?

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